![]() ![]() Of the 4,392 patients who underwent PCI during this study period, 140 patients with restenosis met the inclusion criteria, and 141 patients without restenosis in the same period were selected randomly as controls. It may result in repeated revascularization and poor long-term prognosis for afflicted patients, despite the reduced neointimal hyperplasia and incidence rate of 50% ( 13). Persistent elevation of monocytes may also be a signal of ISR after percutaneous coronary intervention (PCI).Īlthough percutaneous coronary intervention (PCI), a widely-prescribed treatment for symptomatic coronary disease, has proven effective, in-stent restenosis (ISR) remains a clinical challenge. The receiver operating characteristic (ROC) curve analysis showed that the cutoff points of monocyte count and percentage in the ISR prediction were 0.46× 10 9/L and 7.4%, respectively, and those of eosinophil count and percentage were 0.20 × 10 9/L and 2.5%, respectively.Ĭonclusion: This study, with a long-term follow-up, first provides evidence that the elevated monocytes at three postoperative months and baseline eosinophils may be strong early predictors of ISR after drug-eluting stent implantation. Eosinophil count and percentage were associated with ISR (OR: 1.22, 95%CI: 1.09–1.36, P = 0.001 OR: 1.23, 95%CI: 1.07–1.40, P = 0.003, respectively), with ISR most significantly associated with the baseline eosinophils. Results: Significant associations of monocyte count and percentage with ISR were evident, which began at 3 months postoperatively and persisted throughout the follow-up period. The angiographic review was completed within two postoperative years. The hematological and biochemical measurement was collected. A scheduled postoperative follow-up was proceeded in four sessions: 0–3 months, 3–6 months, 6–12 months, and >12 months. Of the 4,392 patients assessed, 140 patients with restenosis and 141 patients without restenosis were enrolled. Methods: The single-center data of patients undergoing successful drug-eluting stents (DES) implantation from Januto Apwere retrospectively analyzed. 2JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, Chinaīackground: Monocytes and eosinophils are involved in intracoronary inflammatory responses, aggravating coronary artery plaque instability and in-stent restenosis (ISR).Īims: To investigate an early prediction of ISR in patients undergoing stenting by circulating monocytes and eosinophils.1Department of Cardiology, Fujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, Fuzhou, China.Shumei Li 1 * †, Hong Qiu 2 †, Zhaorong Lin 1, Lin Fan 1, Yongzhe Guo 1, Yujie Zhang 1 and Lianglong Chen 1 ![]()
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